Monday, 3 February 2025

Yamanaka

 Yamanaka

OpenAI has ventured into protein engineering with the development of a model—GPT4b micro—which enhances the Yamanaka factors.

About Yamanaka Factors:

The Yamanaka Factors consist of four specific proteins: Oct4, Sox2, Klf4, and c-Myc. These transcription factors regulate gene expression and have the ability to reprogram somatic (adult) cells into induced pluripotent stem cells (iPSCs).

Applications:

  • Regenerative Medicine: iPSCs, generated using Yamanaka factors, can differentiate into any type of cell, providing potential treatments for various diseases.
  • Drug Testing: iPSCs offer a platform for testing drug efficacy and toxicity.

Discovery & Recognition:

  • The Yamanaka factors were identified in 2006 by Shinya Yamanaka.
  • Yamanaka was awarded the 2012 Nobel Prize in Physiology or Medicine for this groundbreaking work

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